Immunochemical characterization of the adenine nucleotide translocator. Organ specificity and conformation specificity

Adenine nucleotide translocator in heart.

The adenine nucleotide translocator (ANT) spans the inner mitochondrial membrane and facilitates exchange of cytosolic ADP for ATP within the mitochondrial matrix. ANT represents the most prominent single protein component of the inner mitochondrial membrane (1). However, its role in cardiac disease processes and physiology has only recently been a major focus of attention. ANT participates in ...

Immunochemical specificity of lactate dehydrogenase-X.

Sperm-producing testes of mammals and some birds contain a unique form of lactate dehydrogenase (EC 1.1.1.27) which is a tetramer composed of C subunits, rather than the A and B subunits of lactate dehydrogenase isozymes 1-5. Immunochemical evidence is presented which confirms the hypothesis that the C subunit is encoded in a separate gene from the A and B polypeptides. The evolutionary relatio...

Kinetics and specificity of the adenine nucleotide translocation in rat liver mitochondria.

Immunological specificity of Staphylococal penicillinase

Adenine Nucleotide Translocator Transports Haem Precursors into Mitochondria

Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification. In haem biosynthesis, the haem precursor protoporphyrin IX (PP IX) must be accumulated into the mitochondrial matrix across the inner membrane, but its mechanism is largely unclear. Here we show that adenine nucleotide translocator (ANT), the inne...